Pharmaceutical Preparation Mixing Tank

Overview

Our Batching Mixing Tank are purpose-built for the compounding, dissolution, and bulk holding of liquid pharmaceutical products. Rather than offering a single generic tank design, we configure each vessel around your specific formulation - matching impeller type, shear profile, and process instrumentation to the rheological properties and sensitivity of your drug product.

Available in working volumes from 50L to 1,500L, or more big capacity. every Batching Mixing tank is constructed from pharmaceutical-grade SS316L with electropolished internal surfaces and ASME BPE-compliant connections - designed for cleanability, sterility, and reproducible batch performance.

What Can It Produce?

Our Batching Mixing Tank support a wide range of liquid dosage forms. The agitation and thermal system are configured based on your product type:

Product Category	Typical Products	Key Processing Requirements
Oral Solutions & Syrups	Syrups, oral solutions,	Complete API dissolution; controlled heating; gentle mixing to avoid degradation;
Nasal Sprays	nasal corticosteroids, saline sprays	Low-shear mixing; sterile venting; sub-surface ingredient addition; particulate-free final product
Ophthalmic & Otic Solutions	Eye drops, ear drops, ophthalmic lubricants	Stringent particulate control; sterile processing; minimal shear; sealless mixing option
Topical Liquids & Gels	Lotions, rinses, mouthwashes, topical gels	Polymer hydration control; viscosity build management; wall-scraping for gel formulations

How to Select the Right Mixing Tank

Choosing the correct tank configuration ensures efficient processing, product quality, and long-term reliability. Use the guide below to identify the configuration that matches your formulation:

Step 1 - Determine Your Viscosity Range

Viscosity Range	Typical Products	Recommended Impeller
Low viscosity (1 – 100 cP)	Oral solutions, eye drops, nasal sprays	Marine propeller / Hydrofoil impeller High flow, low shear
Medium viscosity (100 – 1,000 cP)	Syrups, suspensions, lotions	Pitched-blade turbine Combined axial/radial flow
High viscosity (1,000 – 50,000 cP)	Gels, thick suspensions, creams	Anchor scraper agitator Wall-sweeping with PTFE blades

Step 2 - Assess Shear Sensitivity

Shear Profile Required	When to Choose	Configuration
Low shear	Shear-sensitive APIs, protein formulations, ophthalmic solutions	Hydrofoil or marine impeller; controlled tip speed; baffled design to minimize vortex
Medium shear	General dissolution, syrup preparation, standard suspensions	Pitched-blade turbine; VFD adjustable speed for process flexibility
High shear	Powder wetting, deagglomeration, nanosuspensions, gel polymer dispersion	Rotor-stator disperser (top or bottom entry); dual-agitator systems

Step 3 - Match Capacity to Batch Size

Model	Working Volume	Typical Application
PBT-100	70 L	Pilot scale, R&D, small-batch specialty products
PBT-200	150 L	Small-scale production, clinical trial batches
PBT-500	300 L	Medium-volume production; most common general-purpose size
PBT-1000	700 L	Large-batch production for high-volume products
PBT-2000	1,500 L	High-capacity production; multi-product facilities

Not sure which configuration fits your product? Our process engineers offer a free formulation review and will recommend an optimized tank configuration based on your specific formula and production targets.

Core Process Advantages

Formulation-Matched Agitation

Every impeller system is selected based on your product's viscosity, shear sensitivity, and mixing objectives - not from a one-size-fits-all default. This ensures optimal flow patterns, minimal energy input, and consistent batch quality without over-processing or under-mixing.

Uniform Temperature Control

Dimple jacket or half-pipe coil heating delivers even heat distribution across the entire vessel wall. Combined with PID precision control (±0.5 °C) and programmable ramp/ soak profiles, the system maintains accurate temperatures throughout dissolution, holding, and cool-down phases - critical for temperature-sensitive APIs and consistent viscosity control.

Batch Consistency Engineering

Standardized vessel geometry, fixed impeller clearance ratios, and VFD speed control with RPM feedback ensure that every batch follows the same hydrodynamic conditions. Combined with automated recipe execution and electronic batch records, you get reproducible product quality batch after batch.

Hygienic & Cleanable Design

All product-contact surfaces are SS316L with electropolished finish (Ra ≤ 0.4 μm). ASME BPE-compliant sanitary connections, zero dead-leg valve arrangements, and fully drainable vessel design support effective CIP/SIP cycles and minimize microbial contamination risk.

Common Manufacturing Challenges & Solutions

Production Challenge	Impact on Product	How Our Tank Solves It
Slow or incomplete API dissolution	Extended batch times; assay variation; rejected batches	CFD-optimized impeller + baffle design creates targeted bottom-zone flow; controlled temperature ramping accelerates solubility kinetics without degradation
Suspension settling during hold	Dose non-uniformity; content variation across the batch	High-flow low-shear hydrofoil impeller with optimized off-bottom clearance maintains uniform suspension without particle attrition; optional recirculation loop for extended holding
Shear-induced API degradation	Potency loss; formation of degradation impurities	Low-shear impeller selection; controlled tip speed calculation; baffled design eliminates vortex air entrainment; sub-surface ingredient addition option
Foaming during mixing	Volume overflow; product loss; entrapped air affecting filling	Submerged impeller operation; baffled flow pattern; programmable agitation ramp-up; optional vacuum deaeration capability
Polymer lumping (fish eyes) in gels	Uneven viscosity; gritty texture; rejected product	Venturi powder induction system; high-shear pre-mixing zone; staged addition protocol with controlled hydration timing
Microbial contamination risk	Failed bioburden testing; product recalls; regulatory risk	ASME BPE hygienic design; zero dead-leg valves; fully drainable vessel; SIP capable configurations; sterile vent filtration; optional magnetic sealless drive

Technical Specifications

Parameter	BMT-100	BMT-200	BMT-500	BMT-1000	BMT-2000
Total Volume (L)	100	200	500	1000	2000
Working Volume (L)	70	140	350	700	1400
Design Pressure	0.3 MPa (FV / 0.3 MPa gauge)
Design Temperature	0 – 121 °C (SIP capable)
Product Contact Material	SS316L (electropolished Ra ≤ 0.4 μm)
Jacket Material	SS304
Agitator Motor (kW)	0.55 – 1.5	1.1 – 2.2	4.0 – 7.5	7.5– 11	11– 15
Agitator Speed	0 – 300 RPM (VFD adjustable; impeller-dependent)
Heating Method	Electric / Steam / Hot Water (customer specified)
Temperature Control Accuracy	±0.5 °C (PID controlled)

Standard Vessel Connections

DN400 sanitary hinged manway with sight glass
Product inlet / charging port (tri-clamp)
Vent port with 0.22μm hydrophobic PTFE filter housing
Bottom outlet valve (sanitary diaphragm, tank bottom flush)
RTD Pt100 temperature sensor port
Pressure / vacuum gauge port
Sight glass with LED light
CIP spray ball port (optional)
Sanitary sample valve

After-Sales Service & Engineering Support

Pre-Sales Engineering

• Free Formulation Review: Our process engineers analyze your product formula and recommend the optimal impeller type, vessel size, and accessory configuration - no obligation
• 3D Layout Planning: We adapt nozzle positions, discharge heights, and overall dimensions to fit your existing production room layout and downstream equipment
• Scale-Up Consultation: If you're moving from lab to pilot or pilot to production, we provide geometric scaling parameters and process translation guidance

Installation & Commissioning

• On-Site Installation Support: Qualified engineers supervise mechanical installation, piping connections, and electrical commissioning
• Performance Qualification: Mixing uniformity testing, temperature mapping, and calibration verification
• Operator Training: Hands-on training for your production team covering operation, maintenance, and basic troubleshooting

Validation Documentation

• Design Qualification (DQ) protocol and report
• Installation Qualification (IQ) protocol and report
• Operational Qualification (OQ) protocol and report
• Material Test Reports (MTR 3.1.B) for all SS316L product-contact components
• Pressure vessel code certification (PED / ASME, as specified)

After-Sales Support

• Warranty: 12-month comprehensive warranty on all equipment and components
• Spare Parts: Global spare parts availability with priority shipping for production-critical components
• Preventive Maintenance Programs: Scheduled service visits to inspect seals, bearings, calibration, and hygienic condition
• Technical Support Hotline: Direct access to our engineering team for troubleshooting and process questions
• Retrofit & Upgrades: Field upgrades available - add CIP systems, change impeller types, upgrade controls, or expand automation as your needs evolve

Regulatory Compliance

FDA 21 CFR Part 211: cGMP-compliant design with non-reactive, non-absorptive product-contact surfaces
EU GMP Annex 1: Sterile-compatible configurations for aseptic processing applications
ASME BPE: Bio-processing equipment standard - hygienic connections, surface finishes, and drainability
21 CFR Part 11 Ready: Automated control systems support electronic records and electronic signatures
CE Marking / PED: Pressure Equipment Directive certified vessels for the European market

Our Factory

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